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KMID : 0360220140550060854
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Journal of the Korean Ophthalmological Society
2014 Volume.55 No. 6 p.854 ~ p.859
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Comparison of Dorzolamide-Timolol Fixed Combination and Latanoprost, Effects on Intraocular Pressure and Ocular Pulse Amplitude
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Jang Se-Ran
Lee Mar-Vin
Ahn Jae-Hong
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Abstract
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Purpose: To compare dorzolamide-timolol fixed combination (DTFC) and latanoprost with regard to their effects on intraocular pressure (IOP) and ocular pulse amplitude (OPA).
Methods: Sixty eyes of 60 patients with open angle glaucoma or glaucoma suspect were included in the present study. Patients were divided into 2 groups, DTFC-treated (n = 30) and latanoprost-treated (n = 30). IOP and OPA were measured with dynamic contour tonometer (DCT) and Goldmann applanation tonometer (GAT), before and at least 1 month after treatment.
Results: GAT IOP, DCT IOP and OPA decreased by 2.25 ± 2.23 mm Hg, 1.97 ± 2.06 mm Hg, and 0.14 ± 0.88 mm Hg, respectively in the DTFC-treated group. In the latanoprost-treated group, GAT IOP, DCT IOP and OPA was reduced by 2.74 ± 2.96 mm Hg, 2.06 ± 3.50 mm Hg, and 0.69 ± 1.07 mm Hg, respectively. There was no significant difference (p = 0.311) in the decline of IOP between the 2 groups, but OPA of the DTFC-treated group decreased less than the latanoprost-treated group (p = 0.032).
Conclusions: No significant differences were observed in the short-term decline of IOP between the 2 medications. However, the influence of DTFC on OPA appeared negligible in the latanoprost-treated group.
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KEYWORD
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Dorzolamide-timolol fixed combination, Dynamic contour tonometer, Intraocular pressure, Latanoprost, Ocular pulse amplitude
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